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Review
. 1990 Aug;15(8):291-4.
doi: 10.1016/0968-0004(90)90014-3.

Why are proteins O-glycosylated?

N Jentoft  1
Affiliations
Review

Why are proteins O-glycosylated?

N Jentoft. Trends Biochem Sci. 1990 Aug.

Abstract

The O-linked oligosaccharides of glycoproteins are usually clustered within heavily glycosylated regions of the peptide chain. Steric interactions between carbohydrate and peptide within these clusters induce the peptide core to adopt a stiff and extended conformation and this conformational effect appears to represent a major function of O-glycosylation.

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