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Review
. 1990 Aug;15(8):309-14.
doi: 10.1016/0968-0004(90)90020-c.

Beta-galactoside transport in E. coli: a functional dissection of lac permease

H R Kaback  1 , E Bibi, P D Roepe
Affiliations
Review

Beta-galactoside transport in E. coli: a functional dissection of lac permease

H R Kaback et al. Trends Biochem Sci. 1990 Aug.

Abstract

The polytopic membrane protein lac permease harnesses energy from the electrochemical H+ gradient to transport beta-galactosidases against a concentration gradient. Although high-resolution structural information is still lacking, the permease is thought to possess 12 membrane-spanning alpha-helical segments. Various experimental strategies, including site-directed mutagenesis, have been employed to probe the function of this membrane protein at the molecular level.

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