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Comment
. 2011 Nov 1;34(11):1453-4.
doi: 10.5665/sleep.1368.

Searching for the missing heritability

Nathaniel F Watson  1
Affiliations
Comment

Searching for the missing heritability

Nathaniel F Watson. Sleep. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic of causal inference methodology utilized to reveal causal genes for complex traits such as 24-hour REM sleep and wake. In the causal model, the RNA transcript is directly controlled by the DNA locus, and acts upon the phenotypic trait. In the reactive model, the trait is directly controlled by the DNA locus, which is associated with the RNA transcript. In the independent model, both the RNA transcript and trait are controlled by the DNA locus, but independent of one another. This methodology allowed identification of the transcripts most likely to mediate the quantitative trait loci effects (e.g., the causal model) of REM sleep and wake.
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