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. 2010 Oct;25(4):286-8.
doi: 10.5001/omj.2010.83.

Serum γ-glutamyltransferase as Oxidative Stress Marker in Pre-and Postmenopausal Iraqi Women

Omar F Abdul-Rasheed, Ghassan A Al-Shamma, Bushra H Zillo

Serum γ-glutamyltransferase as Oxidative Stress Marker in Pre-and Postmenopausal Iraqi Women

Omar F Abdul-Rasheed et al. Oman Med J. 2010 Oct.

Abstract

Objectives: The primary role of γ-glutamyltransferase is to metabolize reduced glutathione by assimilating and utilizing precursor amino acids for intracellular glutathione synthesis. The aim of this study is to investigate the exact role of γ- glutamyltransferase enzyme in the oxidative stress associated with menopause.

Methods: This study was carried out at the Chemistry and Biochemistry department, Al-Nahrain University from October 2009 to January 2010. The study participants were categorized into two groups; premenopausal group (n=17) and postmenopausal group (n=16). Blood specimens were collected from each participant by vein puncture procedure. The γ-glutamyltransferase enzyme was measured by kinetic spectrophotometric method while glutathione and malondialdehyde were measured by spectrophotometric methods.

Results: Serum glutathione levels in pre- and postmenopausal women were 0.62±0.17 and 0.47±0.11 mmol/L respectively. Serum γ-glutamyltransferase levels increased significantly in the postmenopausal women group (p=0.025) compared to the premenopausal women group. Serum malondialdehyde levels were 1.04±0.06 and 1.32±0.05 μmol/L in pre- and postmenopausal groups respectively.

Conclusion: Serum γ-glutamyltransferase may be considered as an index of oxidative stress associated with menopause.

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Figures

Figure 1
Figure 1
γ-Glutamyl cycle.
See this image and copyright information in PMC

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