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Case Reports
. 2012 Aug;18(4):555-7.
doi: 10.1007/s10156-011-0334-y. Epub 2011 Nov 2.

Adalimumab treatment may replace or enhance the activity of steroids in steroid-refractory tuberculous meningitis

Ho-Su Lee  1 , Yumi Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
Affiliations
Case Reports

Adalimumab treatment may replace or enhance the activity of steroids in steroid-refractory tuberculous meningitis

Ho-Su Lee et al. J Infect Chemother. 2012 Aug.

Abstract

We describe a paradoxical response involving the central nervous system in a patient with steroid-refractory tuberculous meningitis that was unresponsive to systemic corticosteroids but was improved with adalimumab. The immunomodulatory effect of tumor necrosis factor inhibitors may have a role in replacing or enhancing the activity of steroids in the management of steroid-refractory tuberculous meningitis.

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