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Editorial
. 2011 Nov;90(5):839-41.
doi: 10.1189/jlb.0411203.

Editorial: switching on arginase in M2 macrophages

Volker Briken, David M Mosser
Editorial

Editorial: switching on arginase in M2 macrophages

Volker Briken et al. J Leukoc Biol. 2011 Nov.

Abstract

Discussion on report that SOCS levels may play an important role in determining macrophage phenotype and function.

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Figures

Figure 1.
Figure 1.. In M2 macrophages, IL-4 induces an up-regulation of SOCS1 and an induction of arginase activity.
The high ratio of SOCS1:SOCS3 may be exploited as another way to identify M2 macrophages. M1 macrophages fail to induce SOCS1, leading to higher levels of SOCS3 relative to SOCS1 and iNOS induction. How the relative levels of these two SOCS proteins influence NO production in M1 macrophages has not been thoroughly studied, but the involvement of PI3K in determining macrophage phenotype and function has been suggested by this and other work.
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Comment on

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