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. 2011:2011:203805.
doi: 10.1155/2011/203805. Epub 2011 Oct 20.

The lyon clinical olfactory test: validation and measurement of hyposmia and anosmia in healthy and diseased populations

Catherine Rouby  1 , Thierry Thomas-Danguin, Michel Vigouroux, Gabriela Ciuperca, Tao Jiang, Jérôme Alexanian, Mathieu Barges, Isabelle Gallice, Jean-Louis Degraix, Gilles Sicard
Affiliations

The lyon clinical olfactory test: validation and measurement of hyposmia and anosmia in healthy and diseased populations

Catherine Rouby et al. Int J Otolaryngol. 2011.

Abstract

The LCOT is a self-administered test designed to assess olfactory deficits. Altogether, 525 subjects contributed to the validation. Elderly participants were well represented in this sample. In a validation study (study 1), 407 healthy and 17 anosmic volunteers between 15 and 91 years of age underwent threshold, supraliminal detection, and identification testing. Cutoff values for normosmia and hyposmia were calculated and applied in a second study in a group of patients with smell complaints and in a group of Alzheimer patients with age-matched controls. Incidence of smell deficit was estimated at 5.6% in the healthy population of study 1, and at 16% in the elderly control group of study 2. Assessment of the ability of each subtest to discriminate between groups showed that LCOT is relevant to differentiating between perception and identification deficits and between Alzheimer's and hyposmic patients.

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Figures

Figure 1
Figure 1
Means and standard errors of scores for the group of healthy participants classified as hyposmic.
Figure 2
Figure 2
Means and standard errors of scores for gas threshold (GT), supraliminal detection (DP), identification (IP), and their difference (DD) across the 3 groups of study 2 (CONT: control elderly group, ALZ: Alzheimer's patients, PAT: smell clinic patients). Bars with the same letter do not differ significantly.
See this image and copyright information in PMC

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