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. 2011:2011:493697.
doi: 10.1155/2011/493697. Epub 2011 May 4.

Recent advances in the pathogenesis and management of cast nephropathy (myeloma kidney)

Stephanie Stringer  1 , Kolitha Basnayake, Colin Hutchison, Paul Cockwell
Affiliations

Recent advances in the pathogenesis and management of cast nephropathy (myeloma kidney)

Stephanie Stringer et al. Bone Marrow Res. 2011.

Abstract

Multiple myeloma is an incurable plasma cell malignancy that is often accompanied by renal failure; there are a number of potential causes of this, of which cast nephropathy is the most important. Renal failure is highly significant in myeloma, as patient survival can be stratified by the severity of the renal impairment. Consequently, there is an ongoing focus on the pathological basis of cast nephropathy and the optimal treatment regimens in this setting, including effective chemotherapy regimens to reduce light chain production and emerging extracorporeal techniques to remove circulating light chains. This paper bridges recent advances in the pathogenesis and management of cast nephropathy in multiple myeloma.

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Figures

Figure 1
Figure 1
Renal biopsy showing cast nephropathy: distal tubular casts and interstitial inflammation and fibrosis.
Figure 2
Figure 2
Renal handling of LCs.
See this image and copyright information in PMC

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