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. 2011 Dec 28;47(48):12858-60.
doi: 10.1039/c1cc15219j. Epub 2011 Nov 2.

Eu(II)-containing cryptates as contrast agents for ultra-high field strength magnetic resonance imaging

Joel Garcia  1 , Jaladhar Neelavalli, E Mark Haacke, Matthew J Allen
Affiliations

Eu(II)-containing cryptates as contrast agents for ultra-high field strength magnetic resonance imaging

Joel Garcia et al. Chem Commun (Camb). .

Abstract

The relaxivity (contrast-enhancing ability) of Eu(II)-containing cryptates was found to be better than a clinically approved Gd(III)-based agent at 7 T. These cryptates are among a few examples of paramagnetic substances that show an increase in longitudinal relaxivity, r(1), at ultra-high field strength relative to lower field strengths.

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Figures

Fig. 1
Fig. 1
Structures of GdDOTA (DOTA = 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetate) and EuII-containing cryptates 1–3. Coordinated water molecules have been omitted for clarity.
Fig. 2
Fig. 2
(a) T1-weighted MR images of solutions of GdDOTA (1.0 mM in PBS) and 1–3 (1.0 mM in PBS) at 7 T and 19 °C. The diameter of the tubes that were used for imaging was 6 mm. Imaging parameters were TR = 21 ms; TE = 3.26 ms; and resolution = 0.27 × 0.27 × 2 mm3. (b) Comparison of 1/T1 values of the samples from (a) at 7 T and 19 °C. Error bars represent standard error of the mean.
See this image and copyright information in PMC

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