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. 2011 Nov 2;9(1):34.
doi: 10.1186/1546-0096-9-34.

Childhood chronic anterior uveitis associated with vernal keratoconjunctivitis (VKC): successful treatment with topical tacrolimus. Case series

Andrea Taddio  1 , Rolando Cimaz, Roberto Caputo, Cinzia de Libero, Laura Di Grande, Gabriele Simonini, Francesca Mori, Elio Novembre, Neri Pucci
Affiliations

Childhood chronic anterior uveitis associated with vernal keratoconjunctivitis (VKC): successful treatment with topical tacrolimus. Case series

Andrea Taddio et al. Pediatr Rheumatol Online J. .

Abstract

Uveitis treatment involves topical corticosteroids along with cycloplegic-mydriatics. Particularly severe cases may require systemic corticosteroids and immunosuppressive drugs. Vernal keratoconjunctivitis (VKC) treatment consists of a brief period of topical corticosteroids and/or cyclosporine. In patients refractory to traditional treatment, the use of 0.1% topical ophtalmic FK- 506 (tacrolimus) ointment has been occasionally reported.This is the first report of the coexistence of uveitis and VKC. The documented response to topical tacrolimus eyedrop of uveitis and VKC is also of interest, in particular since to our knowledge there are no published reports on its clinical use in uveitis.

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Figures

Figure 1
Figure 1
Giant tarsal follicular conjunctivitis in a patient with Vernal Keratoconjunctivitis (VKC).
See this image and copyright information in PMC

References

    1. Heinz C, Mingels A, Goebel C, Fuchsluger T, Heiligenhaus A. Chronic uveitis in children with and without juvenile idiopathic arthritis: differences in patient characteristics and clinical course. J Rheumatol. 2008;35:1403–7. - PubMed
    1. Cassidy JT, Sullivan DB, Petty RE. Clinical Patterns of chronic iridocyclitis in children with juvenile rheumatoid arthritis. Arthritis Rheum. 1977;20:224–227. - PubMed
    1. Sobrin L, Christen W, Foster CS. Mycophenolate mofetil after methotrexate failure or intolerance in the treatment of scleritis and uveitis. Ophthalmology. 2008;115:1416–21. - PubMed
    1. Simonini G, Zannin ME, Caputo R, Falcini F, de Martino M, Zulian F, Cimaz R. Loss of efficacy during long term infliximab therapy for sight-threatening childhood uveitis. Rheumatology (Oxford) 2008;47:1510–4. - PubMed
    1. Bonini S, Bonini S, Lambiase A, Marchi S, Pasqualetti P, Zuccaro O, Rama P, Magrini L, Juhas T, Bucci MG. Vernal keratoconjunctivitis revisited: a case series of 195 patients with long-term followup. Ophthalmology. 2000;107:1157–1163. - PubMed