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. 2011 Nov 23;133(46):18566-9.
doi: 10.1021/ja208068w. Epub 2011 Nov 2.

Room-temperature C-H arylation: merger of Pd-catalyzed C-H functionalization and visible-light photocatalysis

Dipannita Kalyani  1 , Kate B McMurtrey, Sharon R Neufeldt, Melanie S Sanford
Affiliations

Room-temperature C-H arylation: merger of Pd-catalyzed C-H functionalization and visible-light photocatalysis

Dipannita Kalyani et al. J Am Chem Soc. .

Abstract

This communication describes the development of a room-temperature ligand-directed C-H arylation reaction using aryldiazonium salts. This was achieved by the successful merger of palladium-catalyzed C-H functionalization and visible-light photoredox catalysis. The new method is general for a variety of directing groups and tolerates many common functional groups.

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Figures

Figure 1
Figure 1
Possible Mechanism for Pd/Ru-Catalyzed C–H Arylation Reactions
Scheme 1
Scheme 1
Pd-Catalyzed C–H Arylation with Diaryliodonium Salts
Scheme 2
Scheme 2
Background Reactions with Electron Deficient Aryldiazonium Salts
See this image and copyright information in PMC

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