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Review
. 1990 Apr;54(4):345-53.
doi: 10.1253/jcj.54.345.

Antibody-targeted thrombolytic agents

E Haber  1 , T Quertermous, G R Matsueda, M S Runge, C Bode
Affiliations
Review

Antibody-targeted thrombolytic agents

E Haber et al. Jpn Circ J. 1990 Apr.

Abstract

Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of immunology, molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.

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