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. 2011 Nov;85(5):818-9.
doi: 10.4269/ajtmh.2011.11-0287.

Can we use a lower dose of liposomal amphotericin B for the treatment of mucosal American leishmaniasis?

Valdir S Amato  1 , Felipe F Tuon, Raphael A Camargo, Regina M Souza, Carolina R Santos, Antonio C Nicodemo
Affiliations

Can we use a lower dose of liposomal amphotericin B for the treatment of mucosal American leishmaniasis?

Valdir S Amato et al. Am J Trop Med Hyg. 2011 Nov.

Abstract

Liposomal amphotericin B has been used as an alternative treatment of mucosal leishmaniasis, but the optimal dose is not established. We retrospectively reviewed the clinical outcome of eight patients with mucosal leishmaniasis treated with liposomal amphotericin B. The mean total dose was 35 mg/kg (range 24-50 mg/kg), which resulted in the healing of all the lesions in all patients and no recurrences were observed during the follow-up period (mean 25 months; range 7-40 months).

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Figures

Figure 1.
Figure 1.
(A) Patient no. 8, nasofibrolaryngoscopy of nasal cavities showing mucosal edema and granuloma of nasal septum before treatment and (B) the healed lesion after treatment, allowing the visualization of the middle turbinate.
See this image and copyright information in PMC

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