Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study
- PMID: 2205416
- DOI: 10.1161/01.cir.82.4.1230
Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study
Abstract
To evaluate the consistency, strength, and independence of the relation of carotid atherosclerosis to coronary atherosclerosis, we quantified coronary artery disease risk factors and extent of carotid atherosclerosis (B-mode score) in 343 coronary artery disease patients and 167 disease-free control patients. In univariable analyses, there was a strong association between coronary status and extent of carotid artery disease in men and women older than and younger than 50 years (p less than 0.001 for men and women greater than 50 years, p less than 0.001 for women less than or equal to 50 years, p = 0.045 for men less than or equal to 50). The relation remained strong after control for age in men and women older than 50 years and in women younger than 50 (p less than 0.001 for men and women greater than 50 years, p = 0.003 for women less than or equal to 50) but did not persist after control for age in men younger than 50. Logistic models that included coronary disease risk factors, with or without B-mode score, as independent variables and presence or absence of coronary disease as the outcome variable indicated that the extent of carotid atherosclerosis was a strong, statistically significant independent variable in models for men and women older than 50 years of age. Next, we examined the usefulness of B-mode score as an aid in screening for coronary artery disease in men and women older than 50 years. Classification rules, both including and excluding B-mode score, were developed based on logistic regression and, for comparison, recursive partitioning (decision trees). The performance of these rules and the bias of their performance statistics were estimated. The improved classification of the study sample when B-mode score was incorporated in the rule was statistically significant only for men (p = 0.015). However, the addition of B-mode score was found to 1) increase the median discrimination score for both sex groups based on the logistic model, and 2) yield better sensitivities and specificities for rules based on recursive partitioning. Thus B-mode score is strongly, consistently, and independently associated with coronary artery disease in patients older than 50 and is at least as useful as well-known risk factors for identifying patients with coronary artery disease.
Similar articles
-
Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis.Arterioscler Thromb. 1991 Nov-Dec;11(6):1786-94. doi: 10.1161/01.atv.11.6.1786. Arterioscler Thromb. 1991. PMID: 1931880
-
Progression of carotid atherosclerosis in Japanese patients with coronary artery disease.Stroke. 1992 Jul;23(7):946-51. doi: 10.1161/01.str.23.7.946. Stroke. 1992. PMID: 1615542
-
Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group.Stroke. 1992 Dec;23(12):1752-60. doi: 10.1161/01.str.23.12.1752. Stroke. 1992. PMID: 1448826
-
An evaluation of methods for imaging and quantifying coronary and carotid lumen stenosis and atherosclerosis.Circulation. 1993 Mar;87(3 Suppl):II17-33. Circulation. 1993. PMID: 8443919 Review.
-
Non-invasive evaluation of iliac and carotid atherosclerosis in familial hypercholesterolemia.Beitr Infusionsther. 1988;23:33-8. Beitr Infusionsther. 1988. PMID: 2484780 Review. No abstract available.
Cited by
-
Significance of the intima-media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population.Heart Views. 2011 Oct;12(4):150-6. doi: 10.4103/1995-705X.90901. Heart Views. 2011. PMID: 22574240 Free PMC article.
-
Slow Coronary Flow is Related to Increased Carotid Intima-Media Thickness but Not Pulse Wave Velocity.Korean Circ J. 2011 Nov;41(11):666-70. doi: 10.4070/kcj.2011.41.11.666. Epub 2011 Nov 29. Korean Circ J. 2011. PMID: 22194762 Free PMC article.
-
Association of increased carotid intima-media thickness with the extent of coronary artery disease.Heart. 2004 Nov;90(11):1286-90. doi: 10.1136/hrt.2003.025080. Heart. 2004. PMID: 15486123 Free PMC article.
-
Sequentially based analysis versus image based analysis of Intima Media Thickness in common carotid arteries studies - do major IMT studies underestimate the true relations for cardio- and cerebrovascular risk?Cardiovasc Ultrasound. 2008 Jun 20;6:32. doi: 10.1186/1476-7120-6-32. Cardiovasc Ultrasound. 2008. PMID: 18570651 Free PMC article.
-
Double-lumen Carotid Plaque Associated with Severe Stenosis Treated with Staged Angioplasty: A Case Report.NMC Case Rep J. 2021 Jul 3;8(1):359-365. doi: 10.2176/nmccrj.cr.2020-0205. eCollection 2021. NMC Case Rep J. 2021. PMID: 35079489 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical