ZFP57: KAPturing DNA methylation at imprinted loci
- PMID: 22055179
- DOI: 10.1016/j.molcel.2011.10.008
ZFP57: KAPturing DNA methylation at imprinted loci
Abstract
In this issue of Molecular Cell, Quenneville et al. (2011) characterize the role of ZFP57 in the maintenance of DNA methylation at imprinting control regions (ICRs), revealing an allele-specific binding pattern, binding motif, and interactions with other epigenetic regulators.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions.Mol Cell. 2011 Nov 4;44(3):361-72. doi: 10.1016/j.molcel.2011.08.032. Mol Cell. 2011. PMID: 22055183 Free PMC article.
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