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Review
. 2012 Feb;153(2):265-268.
doi: 10.1016/j.pain.2011.10.004. Epub 2011 Nov 4.

Estimate at your peril: imputation methods for patient withdrawal can bias efficacy outcomes in chronic pain trials using responder analyses

Andrew R Moore  1 , Sebastian Straube, Christopher Eccleston, Sheena Derry, Dominic Aldington, Philip Wiffen, Rae F Bell, Katri Hamunen, Ceri Phillips, Henry McQuay
Affiliations
Review

Estimate at your peril: imputation methods for patient withdrawal can bias efficacy outcomes in chronic pain trials using responder analyses

Andrew R Moore et al. Pain. 2012 Feb.
No abstract available

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References

    1. Arnold LM, Palmer RH, Gendreau RM, Wang Y, Gendreau JF. Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2010;62:2745-2756.
    1. Barnes SA, Mallinckrodt CH, Lindborg SR, Carter MK. The impact of missing data and how it is handled on the rate of false-positive results in drug development. Pharm Stat. 2008;7:215-225.
    1. Buynak R, Shapiro DY, Okamoto A, Van Hove I, Rauschkolb C, Steup A, Lange B, Lange C, Etropolski M. Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled phase III study. Expert Opin Pharmacother. 2010;11:1787-1804.
    1. Clauw DJ, Mease P, Palmer RH, GendreauRM Wang.Y. Milnacipran for the treatment of fibromyalgia in adults: a 15-week, multicenter, randomized, double-blind, placebo-controlled, multiple-dose clinical trial. Clin Ther. 2008;30:1988-2004.
    1. Mease PJ, Crofford LJ, Simpson SL, Young JP Jr, Martin SA, Haig GM, Sharma U. Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin. Pain. 2008;136:419-431.

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