Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Nov 4;9(5):385-6.
doi: 10.1016/j.stem.2011.10.007.

Postnatal neurogenesis in the human forebrain: from two migratory streams to dribbles

Zhengang Yang  1 , Guo-li Ming, Hongjun Song
Affiliations
Comment

Postnatal neurogenesis in the human forebrain: from two migratory streams to dribbles

Zhengang Yang et al. Cell Stem Cell. .

Abstract

Subventricular zone neurogenesis occurs throughout life from rodents to primates, but the existence of a rostral migratory stream of immature neurons in postnatal human brains is controversial. A recent report in Nature (Sanai et al., 2011) identifies two neuronal migratory streams in infant human brains targeting the olfactory bulb and prefrontal cortex.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Neurogenesis in the postnatal human SVZ
(A) In the infant human brain, a large number of neuroblasts derived from the subventricular zone (SVZ) migrate not only into the olfactory bulb (OB) through the rostral migratory stream (RMS), but also into the ventromedial prefrontal cortex (VMPFC) through the medial migratory stream (MMS). (B) In the adult human brain, only few migrating neuroblasts in isolation are present in the SVZ and the remnant RMS. Postnatal migration of neuroblasts occurs in the absence of olfactory ventricular extension.
See this image and copyright information in PMC

Comment on

References

    1. Curtis MA, Kam M, Nannmark U, Anderson MF, Axell MZ, Wikkelso C, Holtas S, van Roon-Mom WM, Bjork-Eriksson T, Nordborg C, et al. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science. 2007;315:1243–1249. - PubMed
    1. Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH. Neurogenesis in the adult human hippocampus. Nat Med. 1998;4:1313–1317. - PubMed
    1. Guerrero-Cazares H, Gonzalez-Perez O, Soriano-Navarro M, Zamora-Berridi G, Garcia-Verdugo JM, Quinones-Hinojosa A. Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain. J Comp Neurol. 2011;519:1165–1180. - PMC - PubMed
    1. Inta D, Alfonso J, von Engelhardt J, Kreuzberg MM, Meyer AH, van Hooft JA, Monyer H. Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone. Proc Natl Acad Sci U S A. 2008;105:20994–20999. - PMC - PubMed
    1. Knoth R, Singec I, Ditter M, Pantazis G, Capetian P, Meyer RP, Horvat V, Volk B, Kempermann G. Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS One. 2010;5:e8809. - PMC - PubMed

LinkOut - more resources