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Comment
. 2011 Nov 4;9(5):388-90.
doi: 10.1016/j.stem.2011.10.014.

Guiding DNA methylation

Alexander Meissner  1
Affiliations
Free article
Comment

Guiding DNA methylation

Alexander Meissner. Cell Stem Cell. .
Free article

Abstract

How DNA methyltransferases, with their limited target specificity, establish cell-type-specific epigenetic patterns is poorly understood. Schübeler and colleagues (Lienert et al., 2011) now show that methylation-determining regions (MDRs) within promoter regions are sufficient to recapitulate endogenous patterns and dynamics of DNA methylation.

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