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Review
. 1990 Jul;97(2-3):273-93.
doi: 10.1016/0022-510x(90)90225-c.

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

B R Bloem  1 , I Irwin, O J Buruma, J Haan, R A Roos, J W Tetrud, J W Langston
Affiliations
Review

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

B R Bloem et al. J Neurol Sci. 1990 Jul.

Abstract

In human and subhuman primates, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces irreversible clinical, biochemical and neuropathological alterations highly reminiscent of those observed in Parkinson's disease. The MPTP model has provided the best available tool to date for the assessment of efficacy and side-effects of symptomatic treatments of Parkinson's disease. In addition, the mechanism of action of MPTP has offered a basis for the development of novel therapeutic strategies aimed at the prevention of Parkinson's disease.

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