Review
[PAF-acether antagonistic pyrrolo[1,2-c]thiazoles: from RP 48740 to RP 59227]
[Article in
French]
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- PMID: 2205718
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Review
[PAF-acether antagonistic pyrrolo[1,2-c]thiazoles: from RP 48740 to RP 59227]
[Article in
French]
J Pharm Belg.
1990 May-Jun.
Abstract
The optimisation of the PAF antagonistic activity of RP 48740 led to the discovery of still more potent molecules of the pyrrolo[1,2-c]thiazole family: RP 52629, RP 52770 and RP 59227. The latter compound, for which a stereo-specific synthesis was developed, exhibits a very high potency as a PAF receptor antagonist.
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