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Review
. 1990 May-Jun;45(3):219-23.

[PAF-acether antagonistic pyrrolo[1,2-c]thiazoles: from RP 48740 to RP 59227]

[Article in French]
D Lavé  1 , C James, H Rajoharison, A Floch, C Robaut, P Sedivy
Affiliations
  • PMID: 2205718
Review

[PAF-acether antagonistic pyrrolo[1,2-c]thiazoles: from RP 48740 to RP 59227]

[Article in French]
D Lavé et al. J Pharm Belg. 1990 May-Jun.

Abstract

The optimisation of the PAF antagonistic activity of RP 48740 led to the discovery of still more potent molecules of the pyrrolo[1,2-c]thiazole family: RP 52629, RP 52770 and RP 59227. The latter compound, for which a stereo-specific synthesis was developed, exhibits a very high potency as a PAF receptor antagonist.

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