Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Jun;31(3):181-5.

Basaloid squamous cell carcinoma of the larynx: report of a early laryngeal cancer

F Soprani  1 , V Armaroli, A Stefanelli, E Emiliani, D Padovani, D Casolino
Affiliations
Case Reports

Basaloid squamous cell carcinoma of the larynx: report of a early laryngeal cancer

F Soprani et al. Acta Otorhinolaryngol Ital. 2011 Jun.

Abstract
in English, Italian

Basaloid squamous cell carcinoma is a recently recognized, rare and aggressive variant of squamous cell carcinoma with a predilection to occur in base of the tongue, hypopharynx and larynx (especially the supraglottic tract). It is usually diagnosed in advanced stage, frequently with distant metastases, requiring aggressive surgical intervention. The prognosis is remarkably poor even after the association of radiotherapy or chemotherapy. Nevertheless recently it has been reported that in the early stage this neoplasm seems to have a behaviour less aggressive, similar to conventional squamous carcinoma. The therapeutic approach is not clearly defined when the neoplasm is diagnosed at an early stage. We present a case of early stage of basaloid squamous cell carcinoma of the supraglottic larynx.

Il carcinoma squamoso basaloide è una variante, recentemente codificata, rara ed aggressiva del carcinoma a cellule squamose con localizzazione preferenziale a livello della base lingua, ipofaringe e laringe (in particolar modo la porzione sovraglottica). Nella maggior parte dei casi è diagnosticato in stadi avanzati, frequentemente con presenza di metastasi a distanza, che richiedono interventi chirurgici demolitivi. La prognosi è solitamente infausta anche dopo associazione di terapia chirurgica e radioterapica. Recentemente, tuttavia, secondo vari studi tale neoplasia negli stadi iniziali sembra avere un comportamento meno aggressivo, simile a quello del carcinoma squamocellulare classico. In tali stadi precoci l'approccio terapeutico non è ancora chiaramente definito. Presentiamo la nostra esperienza in un caso di carcinoma basaloide del laringe ad uno stadio iniziale

Keywords: Basaloid squamous cell carcinoma; Laryngeal tumours; Radiotherapy; Supraglottic larynx.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Videolaryngoscopy image showing a polypoid mass of the right false vocal fold.
Fig. 2.
Fig. 2.
Histological examination revealing the typical aspects of a BSCC of the supraglottic larynx.
Fig. 3.
Fig. 3.
Negative computed tomography (CT) scan of neck.
See this image and copyright information in PMC

References

    1. Paulino AF, Singh B, Shah JP, et al. Basaloid squamous cell carcinoma of the head and neck. Laryngoscope. 2000;110:1479–1482. - PubMed
    1. Campman SC, Gandour-Edwards RF, Sykes JM. Basaloid squamous carcinoma of the head and neck. Report of a case occurring in the anterior floor of the mouth. Arch Pathol Lab Med. 1994;118:1229–1232. - PubMed
    1. Raslan WF, Barnes L, Krause JR, et al. Basaloid squamous cell carcinoma of the head and neck: a clinicopathologic and flow cytometric study of 10 new cases with review of the English literature. Am J Otolaryngol. 1994;15:204–211. - PubMed
    1. Sheen Ts, Chang Y, Ko J, et al. Basaloid squamous cell carcinoma of the larynx. Otolaryngol Head Neck Surg. 1999;121:647–650. - PubMed
    1. Abe K, Sasano H, Itakura Y, et al. Basaloid-squamous carcinoma of the esophagus. A clinicopathologic, DNA ploidy, and immunohistochemical study of seven cases. Am J Surg Pathol. 1996;20:453–461. - PubMed

Publication types

LinkOut - more resources