Animal models for AIDS

Abstract

Animal models will play a central role in AIDS research in the coming years. Important models for human immunodeficiency virus (HIV)-induced disease in humans include HIV-infected great apes, simian immunodeficiency virus-infected Asian monkeys and infections of ungulates and cats with HIV-related lentiviruses. The nature of the diseases induced by these viruses are described here by Norman Letvin, emphasizing aspects with particular relevance to human HIV infections.