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Randomized Controlled Trial
. 2011 Nov-Dec;61(6):702-12.
doi: 10.1016/S0034-7094(11)70079-4.

Citrus aurantium blossom and preoperative anxiety

[Article in English, Multiple languages]
Mahmood Akhlaghi  1 , Gholamreza Shabanian, Mahmoud Rafieian-Kopaei, Neda Parvin, Mitra Saadat, Mohsen Akhlaghi
Affiliations
Free article
Randomized Controlled Trial

Citrus aurantium blossom and preoperative anxiety

[Article in English, Multiple languages]
Mahmood Akhlaghi et al. Rev Bras Anestesiol. 2011 Nov-Dec.
Free article

Abstract

Background and objectives: Reducing anxiety is very important before operation. Preoperative visit and use of premedication are popular methods to achieve this goal, but the role of anxiolytic premedication remains unclear and postoperative side-effects may result from routine premedication. Citrus aurantium is used as an alternative medicine in some countries to treat anxiety, and recently the anxiolytic role of this medicinal plant was established in an animal model study. The aim of this study was to assess the anxiolytic effect of Citrus aurantium blossomon preoperative anxiety.

Methods: We studied 60 ASA I patients undergoing minor operation. In a randomized double-blind design, two groups of 30 patients received one of the following oral premedication two hours before induction of anesthesia: 1) Citrus aurantium blossom distillate 1mL.kg(-1) (C-group); 2) Saline solution 1mL.kg(-1) as placebo (P-group). Anxiety was measured before and after premedication using the Spielberger state-trait anxiety inventory (STAI-state) and the Amsterdam preoperative anxiety and information scale (APAIS) before operation.

Results: After premedication, both the STAI-state and the APAIS scales were decreased in C-group (p<0.05); while exhibiting no significant changes in P-group.

Conclusions: Citrus aurantium blossom may be effective in terms of reduction in preoperative anxiety before minor operation.

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