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. 1990 Oct;116(10):1181-5.
doi: 10.1001/archotol.1990.01870100075016.

HLA class I and class II antigen expression on squamous cell carcinoma of the head and neck

J R Houck  1 , F M Sexton, G Zajdel
Affiliations

HLA class I and class II antigen expression on squamous cell carcinoma of the head and neck

J R Houck et al. Arch Otolaryngol Head Neck Surg. 1990 Oct.

Abstract

We compared human major histocompatibility (HLA) class I and class II antigen expression on squamous cell carcinoma of the head and neck with that on normal mucosa. Frozen sections of a consecutive series of 30 squamous cell carcinomas were stained with the monoclonal antibodies W6/32 (class I) and anti-DR (class II) using an immunoperoxidase technique. Normal mucosa showed class I and class II expression in the basal layers only. Class I expression on tumors was diffuse in 87%, patchy in 10%, and scattered in 3%. Class II expression on tumors was diffuse in 20%, patchy in 53%, scattered in 20%, and absent in 7%. Patterns of expression did not correlate significantly with clinical parameters, including survival, except that class II diffuse and patchy patterns were found to correlate with more poorly differentiated tumors.

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