Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;55(1):32-5.
doi: 10.1007/s00125-011-2354-7. Epub 2011 Nov 8.

Audit of acute Charcot's disease in the UK: the CDUK study

Affiliations

Audit of acute Charcot's disease in the UK: the CDUK study

F L Game et al. Diabetologia. 2012 Jan.

Erratum in

  • Diabetologia. 2012 Mar;55(3):862

Abstract

Aims/hypothesis: We studied factors associated with the development and resolution of acute Charcot foot using a web-based observational study.

Methods: Clinicians managing cases of acute Charcot foot in the UK and Ireland between June 2005 and February 2007 were invited to register anonymised details on a secure website.

Results: A total of 288 cases (age 57.0 ± 11.3 years [mean ± SD]; 71.2% male) were registered from 76 centres. Of these, 36% of patients recalled an episode of relevant trauma in the preceding 6 months, while 12% had had surgery to the affected foot. In 101 (35%) cases, ulceration was present at registration and 20% of these had osteomyelitis. Non-removable off-loading devices were used at presentation in 35.4% of cases, with removable off-loading used in 50%. Data on resolution were available for 219 patients. The median time to resolution was 9 months in patients whose initial management included the use of non-removable off-loading, compared with 12 months in the remainder (p = 0.001). Bisphosphonates were administered intravenously in 25.4% and orally in 19.4% of cases. The median time to resolution in patients who received bisphosphonates was 12 months and was longer than in those who did not (10 months, p = 0.005).

Conclusions/interpretation: The median time to resolution was longer than in earlier series. Although limited by being observational and non-randomised, these data suggest that the use of non-removable off-loading at presentation may shorten the time to resolution. They provide no evidence to indicate that the use of bisphosphonates is beneficial.

PubMed Disclaimer

References

    1. Scand J Surg. 2002;91(2):195-201 - PubMed
    1. Diabetologia. 2002 Aug;45(8):1085-96 - PubMed
    1. Foot Ankle Int. 2006 May;27(5):324-9 - PubMed
    1. J Diabetes Complications. 1998 Sep-Oct;12(5):287-93 - PubMed
    1. Diabetologia. 2001 Nov;44(11):2032-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources