Working with small molecules: preparing and storing stock solutions and determination of kinetic solubility

Abstract

The handling of organic compounds in the laboratory requires the use of organic (co-) solvents to mediate solubility. Advantages and disadvantages of the widely used solvent dimethylsulfoxide (DMSO) are discussed, and guidelines for dissolution and storage of compounds are given. Finally, nephelometry is introduced as a fast method to determine the kinetic solubility of a compound.