Comment
doi: 10.1073/pnas.1115315108.
Epub 2011 Nov 7.
Keeping proteasomes under control--a role for phosphorylation in the nucleus
Affiliations
- PMID: 22065770
- PMCID: PMC3219122
- DOI: 10.1073/pnas.1115315108
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Comment
Keeping proteasomes under control--a role for phosphorylation in the nucleus
Proc Natl Acad Sci U S A.
.
No abstract available
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Role of the 26S proteasomes in degrading ubiquitinated proteins. Polyubiquitinated substrates initially bind to subunits Rpn10 and Rpn13 and become deubiquitinated. This process activates proteolysis (24). Substrates are unfolded by the six ATPase subunits (Rpt1–6), which open the gated pore in the α-ring to allow translocation into the 20S core, where they are cleaved to peptides by the six active sites on β-subunits. This illustration is adapted from the EM images provided by Wolfgang Baumeister (Max Planck Institute, Martinsried, Germany) (25).
Comment on
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UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18649-54. doi: 10.1073/pnas.1113170108. Epub 2011 Sep 26. Proc Natl Acad Sci U S A. 2011. PMID: 21949367 Free PMC article.
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