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Comment
. 2011 Nov 15;108(46):18573-4.
doi: 10.1073/pnas.1115315108. Epub 2011 Nov 7.

Keeping proteasomes under control--a role for phosphorylation in the nucleus

Zhe Sha  1 , Andreas Peth, Alfred L Goldberg
Affiliations
Comment

Keeping proteasomes under control--a role for phosphorylation in the nucleus

Zhe Sha et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Role of the 26S proteasomes in degrading ubiquitinated proteins. Polyubiquitinated substrates initially bind to subunits Rpn10 and Rpn13 and become deubiquitinated. This process activates proteolysis (24). Substrates are unfolded by the six ATPase subunits (Rpt1–6), which open the gated pore in the α-ring to allow translocation into the 20S core, where they are cleaved to peptides by the six active sites on β-subunits. This illustration is adapted from the EM images provided by Wolfgang Baumeister (Max Planck Institute, Martinsried, Germany) (25).
See this image and copyright information in PMC

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References

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