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Review
. 2012 Jan;31(1):13-21.
doi: 10.1007/s10067-011-1877-0. Epub 2011 Nov 9.

An update on the pathology and clinical management of gouty arthritis

Emilio B Gonzalez  1
Affiliations
Review

An update on the pathology and clinical management of gouty arthritis

Emilio B Gonzalez. Clin Rheumatol. 2012 Jan.

Abstract

Gouty arthritis is an inflammatory condition associated with debilitating clinical symptoms, functional impairments, and a substantial impact on quality of life. This condition is initially triggered by the deposition of monosodium urate crystals into the joint space. This causes an inflammatory cascade resulting in the secretion of several proinflammatory cytokines and neutrophil recruitment into the joint. While generally effective, currently available agents are associated with a number of adverse events and contraindications that complicate their use. Based on our increased understanding of the inflammatory pathogenesis of gouty arthritis, several new agents are under development that may provide increased efficacy and reduced toxicity.

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Figures

Fig. 1
Fig. 1
Prevalence of gout in the USA according to age [1, 2]
Fig. 2
Fig. 2
IL-1β signaling leads to recruitment of neutrophils and amplification of an acute inflammatory cascade. IL interleukin, MSU monosodium urate, TNF-α tumor necrosis factor alpha
See this image and copyright information in PMC

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