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Comment
. 2010 Oct;2(10):2333-6; author reply 2337-9.
doi: 10.3390/toxins2102333. Epub 2010 Sep 29.

Comments on "Ochratoxin A: In utero Exposure in Mice Induces Adducts in Testicular DNA. Toxins 2010, 2, 1428-1444"-Mis-Citation of Rat Literature to Justify a Hypothetical Role for Ochratoxin A in Testicular Cancer

Peter G Mantle
Comment

Comments on "Ochratoxin A: In utero Exposure in Mice Induces Adducts in Testicular DNA. Toxins 2010, 2, 1428-1444"-Mis-Citation of Rat Literature to Justify a Hypothetical Role for Ochratoxin A in Testicular Cancer

Peter G Mantle. Toxins (Basel). 2010 Oct.

Abstract

A manuscript in the journal recently cited experimental rat data from two manuscripts to support plausibility of a thesis that ochratoxin A might be a cause of human testicular cancer. I believe that there is no experimental evidence that ochratoxin A produces testicular cancer in rats or mice.

Keywords: DNA adducts; fumonisin B1; mouse testicular tumor; ochratoxin A; rat testicular tumor.

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Figures

Figure 1
Figure 1
Two regions of a testis of an F 344 rat, which ingested OTA (300 µg/kg body weight) daily in feed for 90 weeks, in a longitudinal section (1.0 × 1.8 cm) stained with hematoxylin and eosin showing vascularized seminomas amongst ageing seminiferous tubules. A causal association is not implied for the toxin because testicular tumor is natural in some ageing rats.
See this image and copyright information in PMC

Comment on

References

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