Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2012 Jan;59(1):78-83.
doi: 10.1016/j.jjcc.2011.10.003. Epub 2011 Nov 8.

Determinants of progression of aortic valve stenosis and outcome of adverse events in hemodialysis patients

Mizuho Hoshina  1 , Hiroshi Wada, Kenichi Sakakura, Norifumi Kubo, Nahoko Ikeda, Yoshitaka Sugawara, Takanori Yasu, Junya Ako, Shin-Ichi Momomura
Affiliations
Free article
Comparative Study

Determinants of progression of aortic valve stenosis and outcome of adverse events in hemodialysis patients

Mizuho Hoshina et al. J Cardiol. 2012 Jan.
Free article

Abstract

Background: Hemodialysis (HD) is an important risk factor for progression of aortic valve stenosis (AS). However, there are varying degrees of disease progression among patients with AS on HD. The aim of this study was to find determinants of rapid progression of AS in patients on HD.

Methods: We enrolled 30 patients with AS on HD with a mean follow-up period of 4 years. The peak pressure gradient (PPG) between the initial echocardiography and the last echocardiography at least 3 months interval (ΔPPG) was adopted as the indicator of AS progression. We divided the patients into two groups according to ΔPPG per year [rapid progression (ΔPPG>4.5 mmHg/year), slow progression (ΔPPG<4.5 mmHg/year)] and compared the clinical characteristics between the two groups.

Results: Overall mean ΔPPG was 4.5 mmHg/year. Systolic blood pressure (SBP), serum calcium, and calcium-phosphate product were significantly higher in rapid progression group compared with slow progression group (p<0.05).

Conclusion: High systolic blood pressure, serum calcium, and calcium-phosphate product were associated with rapid progression of AS in patients on chronic HD.

PubMed Disclaimer

Publication types