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. 2010:2010:759868.
doi: 10.1155/2010/759868. Epub 2010 Dec 2.

B-cell pathology in juvenile idiopathic arthritis

V Wiegering  1 , H J Girschick, H Morbach
Affiliations

B-cell pathology in juvenile idiopathic arthritis

V Wiegering et al. Arthritis. 2010.

Abstract

Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA.

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