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Review
. 2011 Nov 11;11(12):837-51.
doi: 10.1038/nri3089.

Peptidoglycan recognition proteins: modulators of the microbiome and inflammation

Julien Royet  1 , Dipika Gupta, Roman Dziarski
Affiliations
Review

Peptidoglycan recognition proteins: modulators of the microbiome and inflammation

Julien Royet et al. Nat Rev Immunol. .

Abstract

All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.

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References

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