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Comment
. 2011 Dec;11(4):194-5.
doi: 10.1016/j.jebdp.2011.09.011.

Low-dose doxycycline plus additional therapies may lower systemic inflammation in postmenopausal women with periodontitis

Walter A Bretz  1
Affiliations
Comment

Low-dose doxycycline plus additional therapies may lower systemic inflammation in postmenopausal women with periodontitis

Walter A Bretz. J Evid Based Dent Pract. 2011 Dec.

Abstract

Article title and bibliographic information: The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial. Payne JB, Golub LM, Stoner JA, Lee H-M, Reinhardt RA, Sorsa T, Slepian MJ. J Am Dent Assoc 2011;142;262-73.

Reviewer: Walter A. Bretz, DDS, PhD.

Purpose/question: To determine whether long-term subantimicrobial-dose-doxycycline (SDD) periodontal therapy could reduce serum biomarkers of systemic inflammation and improve lipid profiles in postmenopausal women who have systemic osteopenia and chronic periodontitis.

Source of funding: NIH/NIDCR grant R01DE012872.

Type of study/design: Randomized controlled trial.

Level of evidence: Level 2: Limited-quality, patient-oriented evidence.

Strength of recommendation grade: Not applicable.

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