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Comment
. 2011 Nov 11;147(4):719-21.
doi: 10.1016/j.cell.2011.10.019.

New driver for lipid synthesis

Sander M Houten  1 , Carmen A Argmann
Affiliations
Free article
Comment

New driver for lipid synthesis

Sander M Houten et al. Cell. .
Free article

Abstract

Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a classic feedback loop. Walker et al. (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity. These findings suggest a link between lipid synthesis and cellular pathways involved in methylation.

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