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Comment
. 2011 Nov 11;147(4):721-3.
doi: 10.1016/j.cell.2011.10.028.

PINK1 and Parkin flag Miro to direct mitochondrial traffic

Lesley A Kane  1 , Richard J Youle
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Free article
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PINK1 and Parkin flag Miro to direct mitochondrial traffic

Lesley A Kane et al. Cell. .
Free article

Abstract

The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PINK1 and Parkin also regulate mitochondrial trafficking and quarantine damaged mitochondria by severing their connection to the microtubule network.

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