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. 2012 Mar-Apr;19(2):181-5.
doi: 10.1136/amiajnl-2011-000492. Epub 2011 Nov 10.

A translational engine at the national scale: informatics for integrating biology and the bedside

Isaac S Kohane  1 , Susanne E Churchill, Shawn N Murphy
Affiliations

A translational engine at the national scale: informatics for integrating biology and the bedside

Isaac S Kohane et al. J Am Med Inform Assoc. 2012 Mar-Apr.

Abstract

Informatics for integrating biology and the bedside (i2b2) seeks to provide the instrumentation for using the informational by-products of health care and the biological materials accumulated through the delivery of health care to conduct discovery research and to study the healthcare system in vivo. This complements existing efforts such as prospective cohort studies or trials outside the delivery of routine health care. i2b2 has been used to generate genome-wide studies at less than one tenth the cost and one tenth the time of conventionally performed studies as well as to identify important risk from commonly used medications. i2b2 has been adopted by over 60 academic health centers internationally.

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Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Informatics for integrating biology and the bedside (i2b2) workbench: the user-facing component of the i2b2 software system.
Figure 2
Figure 2
Geographical distribution of over 60 academic health centers (50 in the USA). Some locations (eg, San Francisco and Boston) have more sites than can be shown at the map's resolution. The map does not include the participants in the CARRAnet or pediatric inflammatory bowel registries.
Figure 3
Figure 3
The informatics for integrating biology and the bedside (i2b2) roadmap forward. The top segment illustrates the tasks of core 1 in i2b2 in developing methodologies to support virtual cohort studies. The segment below outlines the components of virtual cohort studies and below that the three driving biology projects (DBP) described in the next. The bottom segment describes the various components of the open source community contributions to i2b2 that will be supported and/or integrated by core 3. CVD, Cardiovascular disease; NLP, natural language processing.
See this image and copyright information in PMC

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