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. 2012 Feb;138(2):189-94.
doi: 10.1007/s00432-011-1082-1. Epub 2011 Nov 16.

Histopathology of surgically treated renal tumours in young adults: a developing country perspective

Muhammed Mubarak  1 , Javed I Kazi, Rehan Mohsin, Altaf Hashmi, Syed Ali Anwer Naqvi, Syed Adeeb Ul Hassan Rizvi
Affiliations

Histopathology of surgically treated renal tumours in young adults: a developing country perspective

Muhammed Mubarak et al. J Cancer Res Clin Oncol. 2012 Feb.

Abstract

Background: There is no data on the histopathological characteristics of renal tumours in young adults in Pakistan.

Materials and methods: We retrospectively analysed 133 young adults (age: 16 to ≤40 years) who underwent nephrectomy for suspected renal cancer from 1994 till July 2010. The demographical and pathological parameters were determined from original surgical biopsy reports and case files, and analysed.

Results: The mean age of patients was 33.3 ± 6.2 years. Overall, 121 (88.9%) renal tumours were malignant, and 15 (11%) benign. Among malignant tumours, renal cell carcinoma (RCC) was predominant (100/121; 82.6%). The subtypes of RCC included: clear cell RCC, 84 (84%); papillary RCC, 11 (11%), chromophobe RCC, 3 (3%) and sarcomatoid RCC, 2 (2%). Other malignant tumours included: transitional cell carcinoma (9/121; 7.4%), primitive neuroectodermal tumour (5/121; 4.1%), synovial sarcoma (2/121; 1.6%), Non-Hodgkin's lymphoma (2/121; 1.6%), leiomyosarcoma (1/121; 0.8%), malignant fibrous histiocytoma (1/121; 0.8%) and squamous cell carcinoma (1/121; 0.8%). Among benign tumours, there were 11 cases of angiomyolipoma (11/15; 73.3%), three cases of oncocytoma (3/15; 20%) and one case of schwannoma (1/15; 6.6%). Almost two-third (62.7%) patients had stage I/II tumours, 22 (18.1%) stage III and 23 (19%) stage IV disease at the time of surgery.

Conclusion: A wide variety of renal tumours is documented in young adults with large size of the tumours and late presentation in our population.

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References

    1. Abou El Fettouh HI, Cherullo EE, El-Jack M, Al Maslamani Y, Novick AC (2002) Sporadic renal cell carcinoma in young adults: presentation, treatment and outcome. Urology 60:806–810 - PubMed
    1. Ajaz S, Khaliq S, Abid A, Hassan AS, Hashmi A, Sultan G et al (2011) Association of a single nucleotide polymorphism in the promoter region of the VEGF gene with the risk of renal cell carcinoma. Genet Test Mol Biomarkers doi:10.1089/gtmb.2011.0029 - PubMed
    1. Algaba F, Trias I, Scarpelli M, Boccon-Gibod L, Kirkali Z, Poppel HV (2004) Handling and pathology reporting of renal tumor specimens. Europ Urol 45:437–443 - PubMed
    1. Alpers CE (2010) The kidney. In: Kumar V, Abbas AK, Fausto N, Aster JC (eds) Robbins and Cotran pathologic basis of disease, 8th edn. WB Saunders, Philadelphia, pp 905–970
    1. Boykin WH, Bright KE, Zeidman EJ, Thompson IM (1992) Renal tumors in young adults. Urology 40:503–505 - PubMed

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