Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Feb;56(2):1113-5.
doi: 10.1128/AAC.05381-11. Epub 2011 Nov 14.

Micafungin concentrations in the plasma and burn eschar of severely burned patients

Junichi Sasaki  1 , Satoshi Yamanouchi, Daisuke Kudo, Tomoyuki Endo, Ryosuke Nomura, Kiyotsugu Takuma, Shigeki Kushimoto, Yotaro Shinozawa, Satoshi Kishino, Shingo Hori, Naoki Aikawa
Affiliations

Micafungin concentrations in the plasma and burn eschar of severely burned patients

Junichi Sasaki et al. Antimicrob Agents Chemother. 2012 Feb.

Abstract

Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC(90)s of micafungin against clinically important Candida and Aspergillus species.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Aikawa N, Kusachi S, Oda S, Takesue Y, Tanaka H. 2009. Clinical effects of micafungin, a novel echinocandin antifungal agent, on systemic fungal infections in surgery, emergency, and intensive-care medicine: evaluation using the AKOTT algorithm. J. Infect. Chemother. 15:219–227 - PubMed
    1. Azuma J, et al. 2002. Phase I study of micafungin. Jpn. J. Chemother. 50(Suppl 1):104– 147
    1. Azuma J, et al. 2002. Pharmacokinetic study of micafungin. Jpn. J. Chemother. 50(Suppl 1):155–184
    1. Blanchet B, Jullien V, Vinsonneau C, Tod M. 2008. Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients. Clin. Pharmacokinet. 47:635–654 - PubMed
    1. Boucher BA, et al. 1998. Fluconazole pharmacokinetics in burn patients. Antimicrob. Agents Chemother. 42:930–933 - PMC - PubMed

MeSH terms