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Comment
. 2011 Nov 22;108(47):18861-2.
doi: 10.1073/pnas.1116513108. Epub 2011 Nov 14.

Shedding light on the vitamin D-tuberculosis-HIV connection

Susan Realegeno  1 , Robert L Modlin
Affiliations
Comment

Shedding light on the vitamin D-tuberculosis-HIV connection

Susan Realegeno et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Vitamin D and the macrophage antimicrobial response to TB. In the presence of sufficient levels of 25D, activation by TLRs or IFN-γ up-regulates CYP27b1, resulting in conversion to 1,25D followed by induction of antimicrobial peptides that kill M. tuberculosis. This antimicrobial pathway is blocked when levels of 25D are deficient, but can be restored in vitro by 25D supplementation. In HIV-infected individuals that are vitamin D-deficient, the lack of IFN-γ production provides an additional immune deficiency.
See this image and copyright information in PMC

Comment on

References

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