[Duplication of animal model of ulcerative colitis and studies on rehabilitation effect of jianpiling prescription]

Abstract

In this paper, the ulcerative colitis model of rats with immuno-method was reported and the mechanism of using Jianpiling for the treatment of ulcerative colitis was studied. The rats of experimental group were subdivided into 3 subgroups (A, B and C), 15% Jianpiling suspension was given to rats in subgroup A per os, 15% Bupi-Yichang Pill to rats in subgroup B per os, 4.5% SASP suspension to rats in subgroup C, and same amount of saline to rats in the control group. The therapeutic results showed that the anti-diarrhia, anti-infection and repairing function of tissue by Jianpiling were obviously better than those of Bupi-Yichang Pill and SASP. Serological exams also showed that Jianpiling was much better than other therapeutic groups in increasing nonspecific cellular immunity and lowering level of antibody against large intestine and IgG. These results suggested that the mechanism of Jianpiling on ulcerative colitis was realized by increasing cellular immunity, inhibiting humoral immunity and promoting immune modulation.