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. 2011 Dec 27;366(1584):3635-7.
doi: 10.1098/rstb.2011.0074.

Whither systems biology

Anthony A Hyman  1
Affiliations

Whither systems biology

Anthony A Hyman. Philos Trans R Soc Lond B Biol Sci. .

Abstract

Cell biologists are interested in how complexity arises from the interaction of different molecules. However, cells are many orders of magnitude larger than the protein-binding interfaces. To bridge these vast difference in scales, biologists construct hierarchies of organization of cellular structures. I describe how systems biology provides an approach to bridge these different scales.

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Figures

Figure 1.
Figure 1.
Scale in biological analysis. The figure illustrates components of a Caenorhabditis elegans mitotic spindle at different length scales, spanning about six orders of magnitude.
See this image and copyright information in PMC

References

    1. Nurse P. 2000. A long twentieth century of the cell cycle and beyond. Cell 100, 71–7810.1016/S0092-8674(00)81684-0 (doi:10.1016/S0092-8674(00)81684-0) - DOI - DOI - PubMed
    1. Brenner S. 2010. Sequences and consequences. Phil. Trans R. Soc. B 365, 207–21210.1098/rstb.2009.0221 (doi:10.1098/rstb.2009.0221) - DOI - DOI - PMC - PubMed
    1. Simon H. A. 1962. The architecture of complexity. Proc. Am. Phil. Soc. 106, 467–482
    1. Mitchel M. 2009. Complexity: a guided tour. Oxford, UK: Oxford University Press
    1. Ball P. 2004. Critical mass: how one thing leads to another. New York, NY: Farrar, Straus and Giroux

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