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. 2012 Apr;71(4):557-9.
doi: 10.1136/annrheumdis-2011-200276. Epub 2011 Nov 14.

A population-based assessment of live births in women with systemic lupus erythematosus

Evelyne Vinet  1 , Jeremy Labrecque, Christian A Pineau, Ann E Clarke, Yvan St-Pierre, Robert Platt, Sasha Bernatsky
Affiliations

A population-based assessment of live births in women with systemic lupus erythematosus

Evelyne Vinet et al. Ann Rheum Dis. 2012 Apr.

Abstract

Objectives: The authors aim to calculate the number of live births, before and after systemic lupus erythematosus (SLE) diagnosis, in women diagnosed during their reproductive years and to compare this with general population rates.

Methods: The authors identified women with SLE using Quebec administrative databases (1 January 1994 to 31 December 2003). The authors determined the number of live births, and calculated the standardised incidence ratio (SIR) of observed to expected live births.

Results: 1334 women with SLE were identified. Overall, the number of live births over the interval (559) was below that which would be expected (708) (SIR 0.79; 95% CI 0.73 to 0.86). Compared with the general population, live births were substantially lower after SLE diagnosis (SIR 0.62; 95% CI 0.55 to 0.70) than before diagnosis (SIR 1.01; 95% CI 0.90 to 1.13).

Conclusion: After diagnosis, women with SLE have substantially fewer live births than the general population.

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