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. 2011:2011:505247.
doi: 10.5402/2011/505247. Epub 2011 Apr 12.

Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats

Gulam Mohammed Husain  1 , Shyam Sunder Chatterjee, Paras Nath Singh, Vikas Kumar
Affiliations

Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats

Gulam Mohammed Husain et al. ISRN Pharmacol. 2011.

Abstract

Hypericum perforatum is known to have diverse medicinal uses for centuries. The antidepressant activity of Hypericum perforatum is widely accepted and proved in both animal and clinical studies. Present study was undertaken to investigate the effect of Hypericum perforatum in a battery of animal models for metabolic disorder. Hypericum is tested for hypolipidemic activity in normal rats, antiobesity activity in high-fat-diet induced obese rats, and fructose-fed rats. Hypericum was orally administered as suspension in 0.3% carboxymethyl cellulose at the doses of 100 and 200 mg/kg body weight for 15 consecutive days. Hypericum significantly lowered total cholesterol and low-density cholesterol in normal rats. Hypericum significantly inhibited weight gain in high-fat-fed rats. In fructose-fed rats, Hypericum normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity. Taken together, Hypericum could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity.

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Figures

Figure 1
Figure 1
Effect of Hypericum perforatum on body weight changes in high-fat-induced obese rats.
Figure 2
Figure 2
Effect of Hypericum perforatum on average daily food intake in high-fat-induced obese rats.
Figure 3
Figure 3
Effect of Hypericum perforatum on various adipose tissues in high-fat-induced obese rats.
See this image and copyright information in PMC

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