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. 2011:2011:560503.
doi: 10.5402/2011/560503. Epub 2011 Jul 31.

Differentiated thyroid cancer in navarra (Spain): historic cohort results (1987-2003)

María Pilar Salvador Egea  1 , Ana Aranzazu Echegoyen Silanes, Eduardo Layana Echezuri, Emma Anda Apiñariz, Ana Puras Gil, Edelmiro Menéndez Torre, Lluis Forga Llenas, Amaya Sainz de Los Terreros
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Differentiated thyroid cancer in navarra (Spain): historic cohort results (1987-2003)

María Pilar Salvador Egea et al. ISRN Oncol. 2011.

Abstract

Introduction. Navarra has the highest incidence of differentiated thyroid cancer in Spain. The aim of this study was to review its management carried out by the Navarra's multidisciplinary Thyroid Disease Unit, from 1987 to 2003. Material and Methods. 325 patients were studied to find the incidence, prevalence, and prognostic factors. Statistical analysis comprised univariate and multivariate Cox proportional hazards regression models for survival and tumor recurrence. Results. The average annual incidence was 3.6 per 100,000 inhabitants, with a final prevalence of 82.4 per 100,000. Regarding survival and recurrence, statistical significance was observed for stage IV, follicular carcinoma, capsular and prethyroid muscles invasion, and T4 group. Only survival was related to tumour size larger than 40 mm. Only recurrence was related to lymph node metastases and radioiodine dose higher than 100 mCi. Conclusions. Attendance of patients in a functional unit setting has allowed us to classify them into three risk groups.

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Figures

Figure 1
Figure 1
Survival curve of stage IV and rest of stages in the multivariate analysis.
Figure 2
Figure 2
Survival curve of pathological classification in the multivariate analysis.
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