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. 2012 Jan 1;175(1):54-9.
doi: 10.1093/aje/kwr288. Epub 2011 Nov 15.

Secular trends in Helicobacter pylori seroprevalence in adults in the United States: evidence for sustained race/ethnic disparities

Yonatan H Grad  1 , Marc Lipsitch, Allison E Aiello
Affiliations

Secular trends in Helicobacter pylori seroprevalence in adults in the United States: evidence for sustained race/ethnic disparities

Yonatan H Grad et al. Am J Epidemiol. .

Abstract

Helicobacter pylori seroprevalence levels in US adults participating in the continuous National Health and Nutrition Examination Survey (1999-2000) increased with age in all racial/ethnic groups, with significantly higher age-standardized levels in Mexican Americans (64.0%, 95% confidence interval (CI): 58.8, 69.2) and non-Hispanic blacks (52.0%, 95% CI: 48.3, 55.7) compared with non-Hispanic whites (21.2%, 95% CI: 19.1, 23.2). Although seroprevalence levels remained similar to those found in National Health and Nutrition Examination Surveys from 1988 to 1991 among non-Hispanic blacks and Mexican Americans, they were significantly lower in non-Hispanic whites, especially at older ages. The factors driving the decline in H. pylori seroprevalence appear to be acting preferentially on the non-Hispanic white population.

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Figures

Figure 1.
Figure 1.
Helicobacter pylori seropositivity by age in years in the US population (A), non-Hispanic whites (B), non-Hispanic blacks (C), and Mexican Americans (D) in the Third National Health and Nutrition Examination Survey, 1988–1991 (formula image), and the National Health and Nutrition Examination Survey, 1999–2000 (▴). Error bars represent standard error.
See this image and copyright information in PMC

References

    1. Banatvala N, Mayo K, Megraud F, et al. The cohort effect and Helicobacter pylori. J Infect Dis. 1993;168(1):219–221. - PubMed
    1. Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther. 1995;9(suppl 2):33–39. - PubMed
    1. Parsonnet J. The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther. 1995;9(suppl 2):45–51. - PubMed
    1. Roosendaal R, Kuipers EJ, Buitenwerf J, et al. Helicobacter pylori and the birth cohort effect: evidence of a continuous decrease of infection rates in childhood. Am J Gastroenterol. 1997;92(9):1480–1482. - PubMed
    1. Everhart JE, Kruszon-Moran D, Perez-Perez GI, et al. Seroprevalence and ethnic differences in Helicobacter pylori infection among adults in the United States. J Infect Dis. 2000;181(4):1359–1363. - PubMed

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