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Comment
. 2011 Nov 15;25(22):2321-6.
doi: 10.1101/gad.180984.111.

A master CLOCK hard at work brings rhythm to the transcriptome

Isaac Edery  1
Affiliations
Comment

A master CLOCK hard at work brings rhythm to the transcriptome

Isaac Edery. Genes Dev. .

Abstract

In this issue of Genes & Development, Abruzzi et al. (pp. 2374-2386) use chromatin immunoprecipitation (ChIP) tiling array assays (ChIP-chip) to show that physical interactions between circadian (≅24-h) clock machineries and genomes are more widespread than previously thought and provide novel insights into how clocks drive daily rhythms in global gene expression.

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Figures

Figure 1.
Figure 1.
How a master clock transcription factor might drive global rhythms in gene expression, with an emphasis on the Drosophila and mammalian systems. Ovals represent different proteins; some homologs only function as depicted in either Drosophila or mammals. Color-coding of transcription factors and cognate promoter-binding sites (small squares) is meant to signify direct interactions. See the text for more details.
See this image and copyright information in PMC

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References

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