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. 2011 Apr;11(4):247-54.

The impact of Hepatitis C virus infection on kidney transplantation outcomes: A systematic review of 18 observational studies: The impact of HCV on renal transplantation

Zohreh Rostami  1 , Mohammad Hossien Nourbala, Seyed Moayed Alavian, Fatemeh Bieraghdar, Yunes Jahani, Behzad Einollahi
Affiliations

The impact of Hepatitis C virus infection on kidney transplantation outcomes: A systematic review of 18 observational studies: The impact of HCV on renal transplantation

Zohreh Rostami et al. Hepat Mon. 2011 Apr.

Abstract

Background: Hepatitis C virus (HCV) infection occursin 0% to 51% of dialysis patients, and manyHCV-positive patients are urged to undergo kidney transplantation. However, the outcome of renal transplantation in HCV-positive recipients is unknown.

Objectives: Our review aimed to address the outcomesof renal transplantation recipients (RTRs)following kidney transplantation.

Materials and methods: We selected studies that used the adjusted relative risk (aRR) and 95% CI of all-cause mortality and graft loss in HCV-positive compared with HCV-negative RTRs as study endpoints. Cox proportional hazard analysis was usedin all studies to calculate the independent effects of HCV infection on RTR outcomes. Sixteen retrospective cohort studies and 2 clinical trials were selected for our review. Sixteen studies were related to patient survival, and 12 examined graft survival.

Results: The combined hazard ratio in HCV-infected recipients was 1.69-fold (1.33-1.97, p < 0.0001) and 1.56 times (1.22-2.004, p < 0.0001) greaterthan that of HCV-negative recipients for mortality and graft loss, respectively.

Conclusions: Although HCV-infected RTRs have worseoutcomes than HCV-negative RTRs,kidney transplantation is the preferred treatment for patients with HCV infection and end-stage renal disease.

Keywords: Graft survival; Hepatitis C infection; Kidney transplantation; Mortality; Natural history; Outcome assessment; Patient survival.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Summary of literature search and study selection
Figure 2
Figure 2
Hazard ratio in HCV-infected recipients for patient survival
Figure 3
Figure 3
Hazard ratio in HCV-infected recipients for graft survival
Figure 4
Figure 4
publication bias for patient survival
Figure 5
Figure 5
publication bias for graft survival
Figure 6
Figure 6
sensitivity analysis for patient's survival
See this image and copyright information in PMC

References

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