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. 2011 Aug;54(8):329-34.
doi: 10.3345/kjp.2011.54.8.329. Epub 2011 Aug 31.

Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/H1N1 2009 infection

Eun Lee  1 , Ju-Hee Seo, Hyung-Young Kim, Shin Na, Sung-Han Kim, Ji-Won Kwon, Byoung-Ju Kim, Soo-Jong Hong
Affiliations

Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/H1N1 2009 infection

Eun Lee et al. Korean J Pediatr. 2011 Aug.

Abstract

Purpose: The purpose of this article is to describe the clinical and epidemiologic features and outcomes among children hospitalized with pandemic influenza A/H1N1 2009 infection.

Methods: We retrospectively reviewed the charts of hospitalized pediatric patients (<18 years) diagnosed with pandemic influenza A/H1N1 2009 infection by reverse-transcriptase polymerase chain reaction at a tertiary hospital in Seoul, Korea, between September 2009 and February 2010.

Results: A total of 72 children were hospitalized with pandemic influenza A/H1N1 2009 infection (median age, 6.0 years; range, 2 months to 18 years). A total of 40% had at least 1 underlying medical condition, including asthma (17%), malignancies (19%), and heart diseases (17%). Of the 72 patients, 54 (76%) children admitted with H1N1 infection showed radiographic alterations compatible with pneumonia. There was no significant difference in pre-existing conditions between pandemic influenza A/H1N1 infected patients with or without pneumonia. Children with pandemic influenza A/H1N1 pneumonia were more likely to have a lower lymphocyte ratio (P=0.02), higher platelet count (P=0.02), and higher level of serum glucose (P=0.003), and more commonly presented with dyspnea than did those without pneumonia (P=0.04).

Conclusion: No significant differences in age, sex, or presence of preexisting conditions were found between children hospitalized with pandemic influenza A/H1N1 H1N1 influenza infection with pneumonia and those without pneumonia. Higher leukocyte count, higher glucose level, and a lower lymphocyte ratio were associated with the development of pandemic A/H1N1 2009 influenza pneumonia.

Keywords: Children; H1N1; Hospitalization; Pneumonia.

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Figures

Fig. 1
Fig. 1
Seasonal pattern of hospitalization of children for pandemic H1N1 influenza with or without pneumonia.
Fig. 2
Fig. 2
Age distribution of children hospitalized for pandemic H1N1 influenza with or without pneumonia.
See this image and copyright information in PMC

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